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These symptoms occur in one out of every three patients.

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These side effects may be severe enough to cause therapy to be discontinued in one out of every 20 patients.

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The UK Prospective Diabetes Study, a large clinical trial performed in 1980-90s, provided evidence that metformin reduced the rate of adverse cardiovascular outcomes in overweht patients with type 2 diabetes relative to other antihyperglycemic agents.

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Metformin does not cause the pancreas to produce more insulin.

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